Barcelona missed the chance to reclaim the LaLiga summit after suffering a 2-1 derby defeat to Girona, who roared back in the second half to leave Real Madrid top of the table.
Atletico Madrid reached their first Champions League semi-final in nine years, narrowly defeating Barcelona 3-2 on aggregate despite a 2-1 home defeat.
Late goals from Dani Olmo and Robert Lewandowski earned LaLiga leaders Barcelona a hard-fought 2-0 victory over Espanyol.
FC Barcelona hammered Newcastle United F.C. 7-2 to reach the Champions League quarter-finals, while Liverpool F.C., Bayern Munich and Atltico Madrid also advanced.
Lamine Yamal's hat-trick led Barcelona to a 4-1 victory over Villarreal in LaLiga, extending their lead over Real Madrid.
The winners of the tie will face Real Sociedad or Athletic Bilbao in the final. Real Sociedad hold a 1-0 advantage ahead of their second leg in San Sebastian on March 4.
Mario Lemina's early diving header handed Galatasaray a 1-0 victory over Liverpool in their Champions League last-16 first leg on Tuesday.
Real Madrid were held to a 1-1 draw by Girona, allowing Barcelona to potentially extend their lead in LaLiga.
Raphinha scored twice as Barcelona won the Spanish Super Cup after an intense 3-2 victory over Real Madrid in Sunday's final in Jeddah.
Harry Kane scored his 36th goal of the season but Bayern Munich let a second-half lead slip to draw 2-2 with Hamburg SV.
Liverpool shrugged off the absence of Mohamed Salah as midfielder Dominik Szoboszlai scored an 88th-minute penalty to give them a 1-0 Champions League win at Inter Milan.
Dramatic night in the Champions League playoffs as goals, shocks and dominant performances decided the final places in the last 16.
IMAGES from the UEFA Champions League matches played on Wednesday.
IMAGES from UEFA Champions League matches played on Wednesday
Christensen, Rashford on target as Barcelona beat Guadalajara in Copa del Rey
Chelsea parted ways with Enzo Maresca on Thursday, a dramatic fall from grace for the Italian who was named manager of the month for November before the club won just one of their last seven league games to fall out of the Premier League title race.
'The only thing I can do is on the pitch -- to give my all. I won't always be technically perfect, but I will always give 100% for the team.'
Ichhapur tea-seller Shib Shankar Patra is one of two diehard fans handpicked for a special meet-and-greet with Argentine superstar Lionel Messi.
Inter Miami secured their first MLS Cup crown on Saturday, beating the Vancouver Whitecaps 3-1 at Chase Stadium as Rodrigo De Paul and Tadeo Allende struck late from a pair of Lionel Messi assists.
A summary of Wednesday's Champions League first leg quarter-finals between Barcelona and Dortmund and Real Madrid, and Paris St Germain and Aston Villa.
Villarreal fought back to shock Barcelona 3-2 on Sunday, handing the LaLiga champions their first league defeat since late December.
'Being able to finish this way here with my people is what I always dreamed of.'
Barcelona suffered a shock 1-0 LaLiga defeat at Real Sociedad on Sunday that ended their seven-match winning streak in all competitions.
Manchester City squandered a three-goal lead to draw 3-3 with Feyenoord in the Champions League on Tuesday.
Croatian forward Ante Budimir scored twice to help Osasuna earn a shock 4-2 home win over leaders Barcelona.
Manchester City have one just victory from their last 10 games across all competitions.
Barcelona made a disappointing start to their Champions League campaign by losing 2-1 to AS Monaco on Thursday.
Italy's Jannik Sinner lost both his previous Wimbledon duels with Novak Djokovic but turned the tables in emphatic fashion as his power and precision proved too much for the seven-time champion who, at 38, looked every bit his age in a humbling 6-3, 6-3, 6-4 loss.
Paris St Germain closed out the year on a high as they maintained their five-point advantage at the top of the table.
Barcelona scraped to a 2-1 win over Zaragoza while Real Madrid lost by the same margin at Real Betis.
Barcelona joined Real Madrid, Atletico and Real Sociedad in the semi-finals, with the draw set to take place on Wednesday.
'I've never seen the VAR called to review a penalty in a shootout... Never!' the Argentine told a press conference.
A round-up of Wednesday's Champions League quarter-final second leg between Real Madrid and Arsenal, Inter Milan and Bayern Munich.
A summary of Tuesday's Champions League first leg quarter-finals between Arsenal and Real Madrid, and Inter Milan and Bayern Munich.
Manchester City came from behind to beat Club Brugge 3-1 and secure their place in the Champions League playoffs
Real Madrid showed their character by beating Barcelona 2-0 in Sunday's top-of-the-table 'Clasico', leapfrogging their rivals at the La Liga summit after a week in which their pride had taken a beating at home and in Europe. Brazilian teenager Vinicius Jr scored the opener in the 71st minute with a strike that deflected off Gerard Pique, flummoxing goalkeeper Marc-Andre ter Stegen who had made some jaw-dropping saves, and substitute Mariano added the second in added time.
What's absolutely loveable is the Navra Maza Navsacha 2 actor's knack for choosing the perfect look for any outing.
A summary of Saturday's action in Ligue 1, LaLiga and Bundesliga.
Kylian Mbappe was in inspired form, scoring twice to guide Real Madrid to a comeback 4-1 win over visitors Las Palmas on Sunday.
A summary of Wednesday's Champions League Round of 16, Second Leg, matches.
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